Skin Healthspan ∞ Skin Youthfulness
Longevity is naturally associated with centenarians. When studying this population, we find that they lead long, healthy, and fulfilling lives, adopting simple, healthy lifestyles that have a significant impact. These supercentenarians are also prevalent in "blue zones" around the world: the mountains of Sardinia, the Okinawa Islands in Japan, Icaria in Greece, and the Nicoya Peninsula in Costa Rica. They follow four main principles: positive attitudes, conscious eating, natural movement, and authentic connection. The individual genome also plays a role in slowing down physiological changes, particularly longevity genes such as SIRT6 and FOXO3.
Skin Health: Interconnected Skin Longevity Mechanisms
At the skin and cellular level, longevity can be defined as maintaining optimal skin cell function over time to preserve skin quality that exudes health (radiance, softness, elasticity). The longevity genes SIRT6 and FOXO3 (genes over-expressed in centenarians) play a major role in longevity signaling pathways. SIRT6 activates FOXO3 gene, which activates the cell’s mitochondrial activity and the autophagy process. SIRT6 also activates NrF2 (which inhibits oxidative stress) and reduces chronic inflammation by inhibiting NfkB.
At the tissular level, optimizing blood flow to the skin is also crucial, as studies show longevity partly depends on good blood circulation. Maintaining a balanced microbiota is also a key factor in increasing longevity.
All of these mechanisms are interconnected and play a major role in keeping skin radiant, smooth, firm, and elastic, all while maintaining a healthy barrier function. For example, balance in microbiota, autophagy, mitochondrial respiration, and antioxidant enzymes in skin cells all contribute to a radiant glow.
TIMELYS® by Greentech: a natural and effective solution to boost skin longevity
By investigating these different mechanisms and identifying which molecules positively affect them, Greentech developed its new active ingredient: Timelys®, concentrated in Schisandrin. The large family of polyphenols has anti-aging properties, notably through their action on aging markers, leading Greentech to focus on them. Following intensive research, Greentech specifically targeted lignans, a less represented category among polyphenols, capable of increasing life expectancy. This led Greentech to Schisandra, rich in Schisandrin, and known as life long health berries.
Regarding biological efficacy, Timelys® boosts the expression of SIRT6 and FOXO3 genes, playing a crucial role in the pathways that regulate longevity. It increases the autophagic activity of cells via an increase in markers (LAMP2 and LC3A). Timelys® stimulates mitochondrial activity and reduces the anti-inflammatory action of cells by reducing NFkB expression and the release of IL-6 and PGE2. Timelys® also promotes the expression of antioxidant enzymes, SOD2 and catalase, and encourages mitochondrial activity. As a result, the production of free radicals within the cell is reduced, alleviating oxidative stress. Timelys® also boosts the integrity of the skin barrier by modulating the expression of occludin, filaggrin, MDA, and cornifin, improving barrier function and helping in dysbiosis prevention. It also targets elastin and MMP1, providing enhanced dermal integrity and mechanical properties.
Timelys® has been tested in two clinical studies to determine its actions in vivo. Timelys® improves cutaneous microcirculation and reduces trans epidermal water loss. These effects promote skin hydration, restoring skin radiance.
By maintaining cellular health, Timelys® has a preventive function, acting on the skin’s longevity mechanisms such as autophagy, for radiant, smoother skin. Timelys® represents a significant advance in the field of skin longevity, combining the power of nature with cutting-edge scientific innovation to provide a comprehensive solution for preserving and extending skin longevity and life expectancy.
