In order to better determine the direct effects of the skin exposure to the artificial light emitted from the screens that are everywhere in our modern life, Gattefossé and Cytoo have initiated a two-year investigation. The two companies have united technology, expertise and know-how with a first aim: to explore mitochondrial modulation and protection upon artificial visible light exposure.
Unique equipment was designed by Gattefossé to accurately recreate the characteristic light emitted by screens of electronic devices (smartphones, tablets, PC). By using micropatterning technology, a method to guide cell shape and monitor cell fate, Cytoo has developed a High Content Screening assay combining precise control of human dermal fibroblast spreading and sensitive analysis of mitochondrial fusion/ fission dynamics by non-invasive live-cell imaging.
Significant impact on mitochondria
A first series of results has already evidenced that exposure to screens significantly weakens mitochondrial function and dynamics.
Cytoo and Gattefossé have observed a fragmentation of the mitochondrial network alongside loss of quality control and diminished capacity to produce ATP [1].
“Using the Cytoo model, we have been able to demonstrate that screen-emitted light has a tremendous detrimental effect on the mitochondrial network of skin fibroblasts. This research highlights the need for a strategy to protect the skin from everyday artificial light”, explained Nicolas Bechetoille, Skin Biology Research Manager at Gattefossé.
Mitochondria, also termed the powerhouse of cells, produce the energy essential to proper biological function of cells. Mitochondrial quality is finely adjusted by constant reshaping of its structure via a process involving fusion and fission.
For this research, Cytoo has adapted its platform to dermo-cosmetic applications, in particular its models of human skin (EpiScreen™ and FibroScreen™), which allow the screening of biologically active compounds.
“Mitochondrial fission and fusion play critical roles when cells experience metabolic or environmental stresses. Both companies have brought cutting-edge technologies to address a brand-new vision of biological processes implied in skin homeostasis. This collaboration with Gattefossé validates once more the ability of Cytoo to generate innovative and predictive solutions to our partners,” commented Luc Selig, CEO of Cytoo.
This work will be presented at the 2017 IFSCC Conference in Seoul on October 23-25.
